Nucleoside-modified AdoMet analogues for differential methyltransferase targeting.
Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018Nucleoside-modified AdoMet analogues for differential methyltransferase targeting.
Auteurs : Nicolas V. Cornelissen [Allemagne] ; Freideriki Michailidou [Allemagne] ; Fabian Muttach [Allemagne] ; Kristina Rau [Allemagne] ; Andrea Rentmeister [Allemagne]Source :
- Chemical communications (Cambridge, England) [ 1364-548X ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
- analogues et dérivés : Adémétionine.
- composition chimique : Adémétionine, Nucléosides.
- métabolisme : Adémétionine, Methyltransferases, Nucléosides.
- Structure moléculaire.
English descriptors
- KwdEn :
- MESH :
- chemical , analogs & derivatives : S-Adenosylmethionine.
- chemical , chemistry : Nucleosides, S-Adenosylmethionine.
- chemical , metabolism : Methyltransferases, Nucleosides, S-Adenosylmethionine.
- Molecular Structure.
Abstract
Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are powerful tools to site-specifically introduce a variety of functional groups and exhibit potential to be converted only by distinct MTases. Extending the size of the substituent at the sulfur/selenium atom provides selectivity among MTases but is insufficient to discriminate between promiscuous MTases. We present a panel of AdoMet analogues differing in the nucleoside moiety (NM-AdoMets). These NM-AdoMets were efficiently produced by a previously uncharacterized methionine adenosyltransferase (MAT) from methionine and ATP analogues, such as ITP and N6-propargyl-ATP. The N6-modification changed the relative activity of three representative MTases up to 13-fold resulting in discrimination of substrates for the methyl transfer and could also be combined with transfer of allyl and propargyl groups.
DOI: 10.1039/c9cc07807j
PubMed: 31970375
PubMed Central: PMC7030947
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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type="city">Münster</settlement></placeName></affiliation></author><author><name sortKey="Rentmeister, Andrea" sort="Rentmeister, Andrea" uniqKey="Rentmeister A" first="Andrea" last="Rentmeister">Andrea Rentmeister</name><affiliation wicri:level="3"><nlm:affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Münster</region><settlement type="city">Münster</settlement></placeName></affiliation></author></analytic><series><title level="j">Chemical communications (Cambridge, England)</title><idno type="eISSN">1364-548X</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Methyltransferases (metabolism)</term><term>Molecular Structure (MeSH)</term><term>Nucleosides (chemistry)</term><term>Nucleosides (metabolism)</term><term>S-Adenosylmethionine (analogs & derivatives)</term><term>S-Adenosylmethionine (chemistry)</term><term>S-Adenosylmethionine (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adémétionine (analogues et dérivés)</term><term>Adémétionine (composition chimique)</term><term>Adémétionine (métabolisme)</term><term>Methyltransferases (métabolisme)</term><term>Nucléosides (composition chimique)</term><term>Nucléosides (métabolisme)</term><term>Structure moléculaire (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>S-Adenosylmethionine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Nucleosides</term><term>S-Adenosylmethionine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Methyltransferases</term><term>Nucleosides</term><term>S-Adenosylmethionine</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Adémétionine</term></keywords><keywords scheme="MESH" qualifier="composition chimique" xml:lang="fr"><term>Adémétionine</term><term>Nucléosides</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Adémétionine</term><term>Methyltransferases</term><term>Nucléosides</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Molecular Structure</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Structure moléculaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are powerful tools to site-specifically introduce a variety of functional groups and exhibit potential to be converted only by distinct MTases. Extending the size of the substituent at the sulfur/selenium atom provides selectivity among MTases but is insufficient to discriminate between promiscuous MTases. We present a panel of AdoMet analogues differing in the nucleoside moiety (NM-AdoMets). These NM-AdoMets were efficiently produced by a previously uncharacterized methionine adenosyltransferase (MAT) from methionine and ATP analogues, such as ITP and N<sup>6</sup>-propargyl-ATP. The N<sup>6</sup>-modification changed the relative activity of three representative MTases up to 13-fold resulting in discrimination of substrates for the methyl transfer and could also be combined with transfer of allyl and propargyl groups.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31970375</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>28</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1364-548X</ISSN><JournalIssue CitedMedium="Internet"><Volume>56</Volume><Issue>14</Issue><PubDate><Year>2020</Year><Month>Feb</Month><Day>18</Day></PubDate></JournalIssue><Title>Chemical communications (Cambridge, England)</Title><ISOAbbreviation>Chem Commun (Camb)</ISOAbbreviation></Journal><ArticleTitle>Nucleoside-modified AdoMet analogues for differential methyltransferase targeting.</ArticleTitle><Pagination><MedlinePgn>2115-2118</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1039/c9cc07807j</ELocationID><Abstract><AbstractText>Methyltransferases (MTases) modify a wide range of biomolecules using S-adenosyl-l-methionine (AdoMet) as the cosubstrate. Synthetic AdoMet analogues are powerful tools to site-specifically introduce a variety of functional groups and exhibit potential to be converted only by distinct MTases. Extending the size of the substituent at the sulfur/selenium atom provides selectivity among MTases but is insufficient to discriminate between promiscuous MTases. We present a panel of AdoMet analogues differing in the nucleoside moiety (NM-AdoMets). These NM-AdoMets were efficiently produced by a previously uncharacterized methionine adenosyltransferase (MAT) from methionine and ATP analogues, such as ITP and N<sup>6</sup>-propargyl-ATP. The N<sup>6</sup>-modification changed the relative activity of three representative MTases up to 13-fold resulting in discrimination of substrates for the methyl transfer and could also be combined with transfer of allyl and propargyl groups.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cornelissen</LastName><ForeName>Nicolas V</ForeName><Initials>NV</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3625-7612</Identifier><AffiliationInfo><Affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Michailidou</LastName><ForeName>Freideriki</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Muttach</LastName><ForeName>Fabian</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rau</LastName><ForeName>Kristina</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rentmeister</LastName><ForeName>Andrea</ForeName><Initials>A</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3107-4147</Identifier><AffiliationInfo><Affiliation>Department of Chemistry, Institute of Biochemistry, University of Muenster, Wilhelm-Klemm-Straße 2, D-48149 Muenster, Germany. a.rentmeister@uni-muenster.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>772280</GrantID><Acronym>ERC_</Acronym><Agency>European Research Council</Agency><Country>International</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>01</Month><Day>23</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Chem Commun (Camb)</MedlineTA><NlmUniqueID>9610838</NlmUniqueID><ISSNLinking>1359-7345</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009705">Nucleosides</NameOfSubstance></Chemical><Chemical><RegistryNumber>7LP2MPO46S</RegistryNumber><NameOfSubstance UI="D012436">S-Adenosylmethionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.1.1.-</RegistryNumber><NameOfSubstance UI="D008780">Methyltransferases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D008780" MajorTopicYN="N">Methyltransferases</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015394" MajorTopicYN="N">Molecular Structure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009705" MajorTopicYN="N">Nucleosides</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012436" MajorTopicYN="N">S-Adenosylmethionine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>29</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>1</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31970375</ArticleId><ArticleId IdType="doi">10.1039/c9cc07807j</ArticleId><ArticleId IdType="pmc">PMC7030947</ArticleId><ArticleId IdType="mid">EMS85694</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>J Am Chem Soc. 2007 Mar 14;129(10):2758-9</Citation><ArticleIdList><ArticleId IdType="pubmed">17309265</ArticleId></ArticleIdList></Reference><Reference><Citation>Curr Opin Chem Biol. 2017 Apr;37:97-106</Citation><ArticleIdList><ArticleId IdType="pubmed">28259085</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Commun (Camb). 2018 Jan 11;54(5):449-451</Citation><ArticleIdList><ArticleId IdType="pubmed">29184954</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2016 Jan 26;55(5):1917-20</Citation><ArticleIdList><ArticleId IdType="pubmed">26694947</ArticleId></ArticleIdList></Reference><Reference><Citation>ACS Chem Biol. 2013;8(6):1134-9</Citation><ArticleIdList><ArticleId IdType="pubmed">23557731</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Sci. 2015 Feb 1;6(2):1362-1369</Citation><ArticleIdList><ArticleId IdType="pubmed">29560223</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7874-8</Citation><ArticleIdList><ArticleId IdType="pubmed">23794451</ArticleId></ArticleIdList></Reference><Reference><Citation>Chemistry. 2017 May 2;23(25):5988-5993</Citation><ArticleIdList><ArticleId IdType="pubmed">28042932</ArticleId></ArticleIdList></Reference><Reference><Citation>Microbiology. 2015 Mar;161(Pt 3):674-82</Citation><ArticleIdList><ArticleId IdType="pubmed">25717169</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2010 Jul 12;49(30):5170-3</Citation><ArticleIdList><ArticleId IdType="pubmed">20572224</ArticleId></ArticleIdList></Reference><Reference><Citation>Annu Rev Cell Dev Biol. 2001;17:405-33</Citation><ArticleIdList><ArticleId IdType="pubmed">11687495</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2018 May 22;57(21):6342-6346</Citation><ArticleIdList><ArticleId IdType="pubmed">29461645</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Commun (Camb). 2015 Feb 28;51(17):3637-40</Citation><ArticleIdList><ArticleId IdType="pubmed">25642798</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2009;48(48):9092-6</Citation><ArticleIdList><ArticleId IdType="pubmed">19882607</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Chem Soc. 2011 May 25;133(20):7648-51</Citation><ArticleIdList><ArticleId IdType="pubmed">21539310</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2012 Aug;40(14):6765-73</Citation><ArticleIdList><ArticleId IdType="pubmed">22564896</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Biol. 1998 Feb;5(2):91-101</Citation><ArticleIdList><ArticleId IdType="pubmed">9495830</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2009 Jul;37(12):3865-77</Citation><ArticleIdList><ArticleId IdType="pubmed">19386620</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10899-903</Citation><ArticleIdList><ArticleId IdType="pubmed">27511141</ArticleId></ArticleIdList></Reference><Reference><Citation>Anal Biochem. 2014 Apr 1;450:11-9</Citation><ArticleIdList><ArticleId IdType="pubmed">24374249</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2012 Apr 10;51(15):3578-81</Citation><ArticleIdList><ArticleId IdType="pubmed">22344826</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Commun (Camb). 2018 Nov 8;54(90):12718-12721</Citation><ArticleIdList><ArticleId IdType="pubmed">30357150</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Chem Soc. 2013 Jan 23;135(3):1048-56</Citation><ArticleIdList><ArticleId IdType="pubmed">23244065</ArticleId></ArticleIdList></Reference><Reference><Citation>Methods. 2016 Sep 1;107:3-9</Citation><ArticleIdList><ArticleId IdType="pubmed">26884260</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Rev. 2014 Apr 23;114(8):4602-20</Citation><ArticleIdList><ArticleId IdType="pubmed">24580634</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2009;48(50):9546-8</Citation><ArticleIdList><ArticleId IdType="pubmed">19899087</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Rev Mol Cell Biol. 2017 Jan;18(1):31-42</Citation><ArticleIdList><ArticleId IdType="pubmed">27808276</ArticleId></ArticleIdList></Reference><Reference><Citation>Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169</Citation><ArticleIdList><ArticleId IdType="pubmed">27899622</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2017 Jun 1;56(23):6507-6510</Citation><ArticleIdList><ArticleId IdType="pubmed">28471013</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2019 Dec 2;58(49):17583-17588</Citation><ArticleIdList><ArticleId IdType="pubmed">31573135</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2017 May 2;56(19):5182-5200</Citation><ArticleIdList><ArticleId IdType="pubmed">27943567</ArticleId></ArticleIdList></Reference><Reference><Citation>RNA Biol. 2012 May;9(5):577-86</Citation><ArticleIdList><ArticleId IdType="pubmed">22614835</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Chem Soc. 2001 Nov 28;123(47):11608-13</Citation><ArticleIdList><ArticleId IdType="pubmed">11716715</ArticleId></ArticleIdList></Reference><Reference><Citation>RNA Biol. 2017 Sep 2;14(9):1099-1107</Citation><ArticleIdList><ArticleId IdType="pubmed">28440690</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Commun (Camb). 2014 May 4;50(34):4478-81</Citation><ArticleIdList><ArticleId IdType="pubmed">24664183</ArticleId></ArticleIdList></Reference><Reference><Citation>Trends Biochem Sci. 2004 May;29(5):243-9</Citation><ArticleIdList><ArticleId IdType="pubmed">15130560</ArticleId></ArticleIdList></Reference><Reference><Citation>Chem Sci. 2017 Dec 1;8(12):7947-7953</Citation><ArticleIdList><ArticleId IdType="pubmed">29619168</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Chem Biol. 2006 Jan;2(1):31-2</Citation><ArticleIdList><ArticleId IdType="pubmed">16408089</ArticleId></ArticleIdList></Reference><Reference><Citation>Angew Chem Int Ed Engl. 2017 Mar 27;56(14):4033-4036</Citation><ArticleIdList><ArticleId IdType="pubmed">28247461</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Protoc. 2006;1(4):1879-86</Citation><ArticleIdList><ArticleId IdType="pubmed">17487172</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>District de Münster</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Münster</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Cornelissen, Nicolas V" sort="Cornelissen, Nicolas V" uniqKey="Cornelissen N" first="Nicolas V" last="Cornelissen">Nicolas V. Cornelissen</name></region><name sortKey="Michailidou, Freideriki" sort="Michailidou, Freideriki" uniqKey="Michailidou F" first="Freideriki" last="Michailidou">Freideriki Michailidou</name><name sortKey="Muttach, Fabian" sort="Muttach, Fabian" uniqKey="Muttach F" first="Fabian" last="Muttach">Fabian Muttach</name><name sortKey="Rau, Kristina" sort="Rau, Kristina" uniqKey="Rau K" first="Kristina" last="Rau">Kristina Rau</name><name sortKey="Rentmeister, Andrea" sort="Rentmeister, Andrea" uniqKey="Rentmeister A" first="Andrea" last="Rentmeister">Andrea Rentmeister</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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